Melissa Mae Carlton and her husband Tom Carlton have identified a rare genetic mitochondrial condition called PPA2 as the cause of their youngest daughter Molly’s sudden death on Christmas morning, nearly four months ago. This diagnosis comes less than two years after their daughter Abigail’s passing in April 2024 from sepsis, which they now believe stemmed from the same disorder.
Rare Condition Explained
Carlton shared the details with her 152,000 Instagram followers. “Molly had a rare genetic mitochondrial condition called PPA2, and we are almost certain Abigail had it as well,” she stated. The ailment involves a failure of energy production at the cellular level, leading to sudden cardiac events in otherwise healthy children, rather than a structural heart defect.
“It’s considered extremely rare but significantly under-tested,” Carlton noted, adding that she suspects many sudden, unexplained child deaths remain undiagnosed. “Most families only learn about PPA2 after a tragedy, and that needs to change.”
Family’s Ongoing Testing and Grief
The couple, married for 14 years, also share daughter Lily and son Harry. They remain in the midst of genetic testing and have requested prayers as they await results. Molly’s death followed a rapid hospitalization despite quick paramedic response and proximity to a pediatric trauma center.
“Doctors tried all day to help her body recover from this cardiac event but ultimately could not keep her with us,” Carlton recounted. She described leaving the hospital “shell-shocked and terrified” to inform their remaining children of the loss.
Faith Amid Heartbreak
Reflecting on the double tragedy, Carlton admitted initial feelings of betrayal and confusion. “To lose a child and then 18 months later, on Christmas Day, for it to be happening again… Why would God allow this?” she questioned.
Turning to her faith, she holds onto beliefs in a loving Heavenly Father, eternal families, and the promise that all will be made right. Initially announcing Molly’s passing on December 26, Carlton wrote, “On Christmas morning, our sweet Molly girl and her big sister Abi were reunited.” Molly, who often asked when Abigail could return, found comfort in that reunion.
Insights for Other Families
Early medical updates suggested a genetic heart condition, potentially linked to Abigail’s death. Hospital monitoring provided key data unavailable for Abigail. “Any minor illness could trigger a sudden cardiac event,” Carlton explained, urging awareness for families facing sudden unexpected death in children (SUDC).
The influencer, who runs a faith-inspired art shop with 80,000 followers, has openly discussed her grief, including Abigail’s swift decline from stomach pain to loss within hours. She now prioritizes cozy family traditions over perfection, honoring her daughters with “Abi angels,” ornaments, and framed pajamas on the tree.
